INOSITOL IN COMBINATION WITH FOLIC ACID APPLICATION IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME

  • A.N. Rybina International Clinical Center PERSONA, Almaty, Kazakhstan
  • Yu.L. Tyugay International Clinical Center PERSONA, Almaty, Kazakhstan
  • A.S. Tulepova International Clinical Center PERSONA, Almaty, Kazakhstan
  • K.A. Urazymbetova International Clinical Center PERSONA, Almaty, Kazakhstan
  • A.T. Abshekenova International Clinical Center PERSONA, Almaty, Kazakhstan
  • R.K. Valiev International Clinical Center PERSONA, Almaty, Kazakhstan
Keywords: PCOS, inositol, pregnancy, ovulation stimulation, Fertina

Abstract

Introduction. Patients with polycystic ovary syndrome are a rather challenging group for fertility specialists. The combination of endocrine and metabolic disorders in polycystic ovary syndrome (PCOS) requires a personalized approach to each patient conception preparing. Inositol in combination with folic acid is one of the effective implements for metabolic disorders correction in polycystic ovary syndrome.

Objectives: to determine the effectiveness of ovulation stimulation in patients with polycystic ovary syndrome during preparation with inositol and folic acid - Fertina, OrionPharma.

Materials and methods: A prospective study was conducted from January 2019 to June 2019. 30 patients with polycystic ovary syndrome were treated with Fertina combined drug containing 1 g of inositol and 100 μg of folic acid in a daily dose of 4 g of inositol and 400 μg of folic acid for 6 months. The levels of gonadotropins, insulin before and after the course of treatment were determined, ultrasound monitoring of ovulation was carried out for 6 months.

Results: When Fertina prescribing 3 months before ovulation stimulation (OS), the LH / FSH ratio normalization and decreased insulin levels were observed in patients with polycystic ovary syndrome. All 30 patients experienced ovulation, in 16.6% pregnancy occurred during 3 cycles of OS.

References

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Published
2019-09-20
How to Cite
Rybina, A., Tyugay, Y., Tulepova, A., Urazymbetova, K., Abshekenova, A., & Valiev , R. (2019). INOSITOL IN COMBINATION WITH FOLIC ACID APPLICATION IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME. Reproductive Medicine, (3(40), 25-28. Retrieved from https://repromed.org/index.php/journal/article/view/96