• O.A. Gromova Federal State Institution “Federal Research Center «Computer Sciences and Management» of the Russian Academy of Sciences «Institute of Pharmacoinformatics, Moscow
  • I.Yu. Torshin Big Data Storage and Analysis Center, Moscow State University, Moscow
  • V.N. Lokshin International Clinical Center for Reproduction “PERSONA” Kazakhstan, Almaty
  • Sh.K. Karibaeva International Clinical Center for Reproduction “PERSONA” Kazakhstan, Almaty
  • D.R. Kaydarova Kazakh Research Institute of Oncology and Radiology (KazRIO&R). Kazakhstan, Almaty
  • O.V. Shatkovskaya Kazakh Research Institute of Oncology and Radiology (KazRIO&R). Kazakhstan, Almaty
Keywords: Vitamin D, Breast Cancer, Dose Dependence, Detrifors® / Detrimax®


In addition to the «bone» effects of vitamin D3, it affects cell proliferation, differentiation and apoptosis, as well as modulates the immune system activity and regulates body weight. Therefore, vitamin D3 deficiency increases risk of tumors. Conversely, vitamin D3 donations contribute to the apoptosis of tumor cells, decrease of the breast tumor formation risk, and prognosis improvement in patients with preformed tumors.


Saez ME, Ramirez-Lorca R, Moron FJ, Ruiz A. The therapeutic potential of the calpain family: new aspects. Drug Discov Today. 2006;11(19-20):917-23.

Garland CF, Garland FC. Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol. 1980;9(3):227- 231.

Ingraham BA, Bragdon B, Nohe A. Molecular basis of the potential of vitamin D to prevent cancer. Curr Med Res Opin. 2008;24(1):139-149.

Громова О.А., Торшин И. Ю. Витамин D. Смена парадигмы; под ред. Е. И. Гусева, И. Н. Захаровой. — Москва : ГЭОТАР-Медиа, 2017. — 568 с. : ил. ; 25 см. — Библиогр. в конце гл. — 3000 (1-й з-д 500) экз. — ISBN 978-5-9704- 4058-2.

Westerdahl J, Ingvar C, Masback A, Jonsson N, Olsson H. Risk of cutaneous malignant melanoma in relation to use of sunbeds: further evidence for UV-A carcinogenicity. Br J Cancer. 2000;82(9):1593-1599.

Torshin I.Yu. Sensing the change from molecular genetics to personalized medicine. Nova Biomedical Books, NY, USA, 2009, In “Bioinformatics in the Post-Genomic Era” series, ISBN 1-60692-217-0.

Nagpal, S, Songqing N, and Radhakrishnan, R (2005) Noncalcemic Actions of Vitamin D Receptor Ligands Full Text Endocrine Reviews 26 (5): 662-687.

Yee YK, Chintalacharuvu SR, Lu J, Nagpal S. Vitamin D receptor modulators for inflammation and cancer. Mini Rev Med Chem. 2005;5(8):761-778.

Martin S. New agents in clinical oncology. //IDrugs. — 2007 Feb;10(2): — 99-101

Gilad LA, Bresler T. Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells. J Endocrinol. 2005;185(3):577-592.

Gilad LA, Schwartz B. Association of estrogen receptor beta with plasma-membrane caveola components: implication in control of vitamin D receptor. J Mol Endocrinol. 2007;38(6):603.

Abbas S, Linseisen J, Slanger T. Serum 25-hydroxyvitamin D and risk of post-menopausal breast cancer--results of a large case-control study. Carcinogenesis. 2008;29(1):93-9.

Ding EL, Mehta S, Fawzi WW, Giovannucci EL. Interaction of estrogen therapy with calcium and vitamin D supplementation on colorectal cancer risk: reanalysis of Women’s Health Initiative randomized trial. Int J Cancer. 2008;122(8):1690-1694.

Kuzmickiene I, Atkocius V, Aleknavicius E, Ostapenko V. Impact of season of diagnosis on mortality among breast cancer survivors.J Cancer Res Ther. 2018 Dec;14(Supplement):S1091-S1097. doi: 10.4103/0973-1482.191064. PMID: 30539851

Roy S, Vallepu S, Barrios C, Hunter K. Comparison of Comorbid Conditions Between Cancer Survivors and Age-Matched Patients Without Cancer.J Clin Med Res. 2018 Dec;10(12):911-919. doi: 10.14740/jocmr3617w. Epub 2018 Oct 30. PMID: 30425764

Wang D, Velez de-la-Paz OI, Zhai JX, Liu DW. Serum 25-hydroxyvitamin D and breast cancer risk: a meta-analysis of prospective studies. Tumour Biol. 2013;34(6):3509-17 doi.

Bauer SR, Hankinson SE, Bertone-Johnson ER, Ding EL. Plasma vitamin D levels, menopause, and risk of breast cancer: dose-response meta-analysis of prospective studies. Medicine (Baltimore). 2013;92(3):123-31.

Chen P, Li M, Gu X, Liu Y, Li X, Li C, Wang Y. Higher blood 25(OH)D level may reduce the breast cancer risk: evidence from a Chinese population based case-control study and meta-analysis of the observational studies. PLoS One. 2013;8(1):e49312.

Mohr SB, Gorham ED, Alcaraz JE, Kane CJ, Macera CA, Parsons JK, Wingard DL, Garland CF. Serum 25-hydroxyvitamin D and prevention of breast cancer: pooled analysis. Anticancer Res. 2011;31(9):2939-2948.

Kim Y, Je Y. Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: a meta-analysis. Br J Cancer. 2014;110(11):2772-84.

Hu K, Callen DF, Li J, Zheng H. Circulating Vitamin D and Overall Survival in Breast Cancer Patients: A Dose-Response Meta-Analysis of Cohort Studies.Integr Cancer Ther. 2018 Jun;17(2):217-225. doi: 10.1177/1534735417712007. Epub 2017 Jun 7. PMID: 28589744

Chung M, Lee J, Terasawa T, Lau J, Trikalinos TA. Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med. 2011;155(12):827-38.

McCullough ML, Zoltick ES, Weinstein SJ, Fedirko V, Wang M, Cook NR, Eliassen AH, Zeleniuch-Jacquotte A, Agnoli C, Albanes D, Barnett MJ, Buring JE, Campbell PT, Clendenen TV, Freedman ND, Gapstur SM, Giovannucci EL, Goodman GG, Haiman CA, Ho GYF, Horst RL, Hou T, Huang WY, Jenab M, Jones ME, Joshu CE, Krogh V, Lee IM, Lee JE, Mannisto S, Le Marchand L, Mondul AM, Neuhouser ML, Platz EA, Purdue MP, Riboli E, Robsahm TE, Rohan TE, Sasazuki S, Schoemaker MJ, Sieri S, Stampfer MJ, Swerdlow AJ, Thomson CA, Tretli S, Tsugane S, Ursin G, Visvanathan K, White KK, Wu K, Yaun SS, Zhang X, Willett WC, Gail MH, Ziegler RG, Smith-Warner SA. Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts.J Natl Cancer Inst. 2018 Jun 14. pii: 5035027. doi: 10.1093/jnci/ djy087. PMID: 29912394

Yang J, Zhu S, Lin G, Song C, He Z. Vitamin D enhances omega-3 polyunsaturated fatty acids-induced apoptosis in breast cancer cells.Cell Biol Int. 2017 Aug;41(8):890-897. doi: 10.1002/cbin.10806. PMID: 28627723

de Sousa Almeida-Filho B, De Luca Vespoli H, Pessoa EC, Machado M, Nahas-Neto J, Nahas EAP. Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women.J Steroid Biochem Mol Biol. 2017 Nov;174:284-289. doi: 10.1016/j.jsbmb.2017.10.009. Epub 2017 Oct 12. PMID: 29031688

Karthikayan A, Sureshkumar S, Kadambari D, Vijayakumar C. Low serum 25-hydroxy vitamin D levels are associated with aggressive breast cancer variants and poor prognostic factors in patients with breast carcinoma.Arch Endocrinol Metab. 2018 Aug;62(4):452-459. doi: 10.20945/2359-3997000000062. PMID: 30304110

Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression.Nat Rev Cancer. 2014 May;14(5):342-57. doi: 10.1038/nrc3691. Epub 2014 Apr 4. PMID: 24705652

Chen P, Hu P, Xie D, Qin Y, Wang F, Wang H. Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Breast Cancer Res Treat. 2010;121(2):469-77.

Zheng Y, Zhu J, Zhou M, Cui L, Yao W, Liu Y. Meta-analysis of long-term vitamin D supplementation on overall mortality. PLoS One. 2013;8(12):e8210.

Isenring EA, Teleni L, Woodman RJ, Kimlin MG, Walpole E, Karapetis CS, Shawgi S, Kichenadasse G, Marshall S, Koczwara B. Serum vitamin D decreases during chemotherapy: an Australian prospective cohort study.Asia Pac J Clin Nutr. 2018;27(5):962-967. doi: 10.6133/apjcn.042018.01. PMID: 30272842

Громова О.А., Торшин И.Ю., Лиманова О.А., Громов А.Н., Керимкулова Н.В. Сравнительное исследование доказа- тельной базы эффективности и безопасности применения пероральной и трансдермальной форм заместительной гормональной терапии эстрогенами у женщин в различные возрастные периоды. Проблемы репродукции, 2013.-N 6.- С.86-96.

Wang K, Li F, Chen L, Lai YM, Zhang X, Li HY. Change in risk of breast cancer after receiving hormone replacement therapy by considering effect-modifiers: a systematic review and dose-response meta-analysis of prospective studies. Oncotarget. 2017 Aug 11;8(46):81109-81124. doi: 10.18632/oncotarget.20154.

Heiss G, Wallace R, Anderson GL, Aragaki A, Beresford SA, Brzyski R, Chlebowski RT, Gass M, LaCroix A, Manson JE, Prentice RL, Rossouw J, Stefanick ML. Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin. JAMA. 2008;299(9):1036-1045.

Ettinger B, Wang SM, Leslie RS, Patel BV, Boulware MJ, Mann ME, McBride M. Evolution of postmenopausal hormone therapy between 2002 and 2009. Menopause. 2012;19(6):610-5.

Jacot W, Firmin N, Roca L, Topart D, Gallet S, Durigova A, Mirr S, Abach L, Pouderoux S, D’Hondt V, Bleuse JP, Lamy PJ, Romieu G. Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study.Ann Oncol. 2016 Jul;27(7):1235-41. doi: 10.1093/annonc/mdw145. Epub 2016 Mar 30. PMID: 27029707

Громова О.А., Торшин И.Ю., Сухих Г.Т., Тетруашвили Н.К. Об эффективных и безопасных дозировках витамина D3: «мега-анализ» клинически результативных исследований как основа доказательности. Акушерство и гинеколо- гия, 2019, №3.

How to Cite
Gromova, O., Torshin, I., Lokshin, V., Karibaeva, S., Kaydarova, D., & Shatkovskaya , O. (2019). VITAMIN D3 IN BREAST TUMOR PREVENTION AND THERAPY. Reproductive Medicine, (3(40), 18-24. Retrieved from